123 articles - From Friday Jul 22 2022 to Friday Jul 29 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Hepatology |
meta-analyses and systematic reviews
| Clin Gastroenterol Hepatol |
Comparative Burden of Metabolic Dysfunction in Lean NAFLD vs. Non-Lean NAFLD - A Systematic Review and Meta-Analysis. The current analysis highlights the weight-dependent nature of metabolic dysfunction in NAFLD. Lean subjects with NAFLD were significantly less metabolically unhealthy than were obese and overweight persons with NAFLD. An overreliance on metabolic dysfunction in defining fatty liver will be a flaw in potentially excluding previously characterized NAFLD. |
Epidemiology and Healthcare Utilization in Patients with Gastroparesis: A Systematic Review. There is a paucity of high-quality, demographically diverse, and population-based studies to accurately describe the epidemiology of GP. Future studies with valid GE measurement are needed to better characterize the epidemiology and natural history of GP. |
Global Hospitalization Trends for Crohn's Disease and Ulcerative Colitis in the 21st Century: A Systematic Review with Temporal Analyses. Hospitalization rates for IBD are stabilizing in countries in Stage 3, whereas newly industrialized countries in Stage 2 have rapidly rising hospitalization rates, contributing to an increasing burden on global healthcare systems. |
Paternal Medications in Inflammatory Bowel Disease and Male Fertility and Reproductive Outcomes: A Systematic Review and Meta-Analysis. Biologic, thiopurine, or methotrexate use among male patients with IBD are not associated with impairments in fertility or with increased odds of adverse pregnancy outcomes. Key words Biologic therapy, congenital malformations, early pregnancy loss, father, inflammatory bowel disease, male, pregnancy outcomes, preterm birth, reproductive health. |
| Gastrointest Endosc |
RELIABILITY OF PREOPERATIVE PANCREATIC NEUROENDOCRINE TUMORS GRADING ON ENDOSCOPIC ULTRASOUND SPECIMENS: A SYSTEMATIC REVIEW WITH META-ANALYSIS OF AGGREGATE AND INDIVIDUAL DATA. EUS is an accurate technique in defining grading in patients with PanNENs, but there is still a margin of error that will need to be focused on with future studies to minimize the risk of over/undertreatment. |
| Gut |
GWAS meta-analysis of 16 790 patients with Barrett's oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level. Our findings provide further insights into BE/EA aetiology and its relationship to risk factors. The results lay the foundation for future follow-up studies to identify underlying disease mechanisms and improving risk prediction. |
Non-alcoholic fatty liver disease and risk of new-onset heart failure: an updated meta-analysis of about 11 million individuals. NAFLD is associated with a 1.5-fold higher long-term risk of new-onset HF, regardless of the presence of diabetes, hypertension and other common cardiovascular risk factors. However, the observational design of the studies does not allow for proving causality. |
| Inflamm Bowel Dis |
Endoscopic Stenting in Crohn's Disease-related Strictures: A Systematic Review and Meta-analysis of Outcomes. Endoscopic stenting in CD-related strictures is a safe technique that can be performed with technical ease, albeit with a limited clinical success. Postprocedure abdominal pain and proximal stent migration are some of the common adverse events reported. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
Effectiveness and safety of vedolizumab in a matched cohort of elderly and nonelderly patients with inflammatory bowel disease: the IG-IBD LIVE study. Vedolizumab can be considered a safe option in elderly IBD patients. Its effectiveness in elderly UC patients may be reduced, while no age-dependent effect on effectiveness was observed in CD. |
Real-world experience of switching from intravenous to subcutaneous vedolizumab maintenance treatment for inflammatory bowel diseases. Switching from IV to SC vedolizumab maintenance treatment is effective in patients with CD or UC. However, 9% of patients were switched back to IV vedolizumab due to adverse events or fear of needles. |
Transmural healing evaluated by magnetic resonance enterography in paediatric patients with Crohn's disease receiving maintenance treatment with biologics. TH is a more stringent goal than EH. Regular follow-up evaluation of transmural status, and efforts to achieve TH, may alter the natural course of CD in the era of treat-to-target. |
TRIM26 inhibits hepatitis B virus replication by promoting HBx degradation and TRIM26 genetic polymorphism predicts PegIFNa treatment response of HBeAg-positive chronic hepatitis B Patients. TRIM26 inhibits HBV replication; IFN promotes TRIM26 expression. TRIM26 exerts an inhibitory effect on HBx by promoting ubiquitin-mediated degradation of HBx. Furthermore, TRIM26 rs116806878 is a potential predictive biomarker of response to PegIFNa in patients with CHB. |
Universal HBV vaccination dramatically reduces the prevalence of HBV infection and incidence of hepatocellular carcinoma. Universal HBV vaccination markedly reduces the prevalence of chronic HBV infection and may contribute to the decreased incidences of HCC and hepatic events. |
| Am J Gastroenterol |
Idiosyncratic Drug-Induced Liver Injury Associated with and Without Drug-Reaction with Eosinophilia and Systemic Symptoms. A limited number of drugs cause DwD, representing a fifth of patients with DILI. DwD is characterized by lesser degrees of liver injury and mortality likely due to earlier presentation. |
Pediatric to adult transfer of care in patients with pancreas disease: Recommendations for care and research opportunities. We emphasize the unique needs of these patients as they transfer to adult healthcare and the need for further research. The goal of improved transitional care and transfer is to enhance the services provided to adolescents/young adults with pancreatic disease in both healthcare settings and improve continuity of follow-up care. |
REDUCTION IN NOSOCOMIAL INFECTIONS IN PATIENTS with CIRRHOSIS DURING THE COVID-19 ERA COMPARED TO PRE-COVID-19: IMPACT OF MASKING AND RESTRICTING VISITATION? We found that despite a higher admission MELD-Na, qSOFA and WBC count, and requiring a longer ICU stay, COVID-era patients developed lower NIs (3% vs 10%, p<0.001) and had higher liver transplant rates versus pre-COVID patients. COVID-era restrictions could reduce NI in critically ill patients with cirrhosis. |
| Clin Gastroenterol Hepatol |
Artificial intelligence-assisted colonoscopy for colorectal cancer screening: a multicenter randomized controlled trial. In this multicenter RCT in asymptomatic patients, AI-assisted colonoscopy improved overall ADR, advanced ADR and ADR of both expert and non-expert attending endoscopists. |
Differential relapse patterns after discontinuation of entecavir vs tenofovir disoproxil fumarate in chronic hepatitis B. TDF and ETV have differential relapse patterns but are associated with similar rates of HBsAg loss and retreatment following discontinuation. Finite therapy can be considered for CHB patients on either TDF or ETV therapy. |
Patient Preferences for Colorectal Cancer Screening Tests in Light of Lowering the Screening Age to 45 Years. Our findings suggest that more than a third of people may want to do a FIT-fecal DNA every three years for their CRC screening. When only considering US MSTF tier 1 tests, three-fourths of people may prefer an annual FIT over colonoscopy. Further research examining CRC screening test preferences among broader populations is warranted to inform and enhance screening programs. |
| Endoscopy |
Risk of residual neoplasia after a non-curative colorectal ESD for malignant lesions; a multinational study. Lymphatic permeation or poor differentiation warrants surgery due to the high risk of lymph node metastasis, mainly in >SM1 cancers. In the remaining cases, en-bloc and R0 resections determine low risk of residual lesion in the wall. Our scores can be a useful tool for the management of patients submitted to non-curative colorectal ESDs. |
| Gastroenterology |
Development, validation and evaluation of the Pediatric Inflammatory Crohn's Magnetic Resonance Enterography Index (PICMI) from the ImageKids study. The PICMI is a valid, reliable and responsive index for assessing transmural inflammation in pediatric CD. It scores the entire bowel length and does not require intravenous contrast or rectal enema and therefore is suitable for use in children. |
Independent validation and assay standardization of improved metabolic biomarker signature to differentiate pancreatic ductal adenocarcinoma from chronic pancreatitis. The single-platform, single-run, m-Metabolic signature of just four metabolites used in combination with serum CA19-9 levels is an innovative accurate diagnostic tool for PDAC at the time of clinical presentation, warranting further large-scale evaluation. |
SMAD4 suppresses colitis-associated carcinoma through inhibition of CCL20/CCR6-mediated inflammation. Regulation of mucosal inflammation is central to SMAD4 tumor suppressor function in the colon. A key downstream node in this regulation is suppression of epithelial CCL20 signaling to CCR6 in immune cells. Loss of SMAD4 in the colon epithelium increases CCL20 expression and chemoattraction of CCR6+ immune cells, contributing to greater susceptibility to colon cancer. |
The Ephrin B2 Receptor Tyrosine Kinase is a Regulator of Proto-oncogene MYC and Molecular Programs Central to Barrett's Neoplasia. The EphB2 signaling is frequently hyperactivated across the BE-EAC continuum. EphB2 is an upstream-regulator of MYC, and activation of EphB2-MYC axis likely precedes BE development. Targeting EphB2/MYC could be a promising therapeutic strategy for this often refractory and aggressive cancer. |
| Gastrointest Endosc |
Comparison of Endoscopic Sleeve Gastroplasty versus Surgical Sleeve Gastrectomy: a Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program Database Analysis. ESG demonstrates a comparable major adverse event rate to SG. Race did not impact short-term AE after ESG. Further prospective studies long term studies are needed to compare ESG with SG. |
EUS-guided gastroenterostomy versus duodenal self-expandable metal stent for malignant gastric outlet obstruction: Results from a nationwide multicenter retrospective study. EUS-GE seems to have improved patency outcomes when compared with D-SEMS for palliative treatment of malignant GOO. Prospective trials are needed to fully compare their efficacy and adverse event profile. |
| Gut |
Microbial determinants of effective donors in faecal microbiota transplantation for UC. Donor microbiota stability and species evenness were identified as novel metrics that were associated with therapeutic efficacy in UC, beyond individual microbial species or metabolites. These metrics may represent community resilience that translates to better engraftment in the host. |
| Hepatology |
Direct chemical induction of hepatocyte-like cells with capacity for liver repopulation. Our findings show that direct chemical reprogramming can generate hepatocyte-like cells with high-quality physiological properties, providing a paradigm for establishing hepatocyte identity in fibroblasts, and demonstrating the potential for chemical reprogramming in organ/tissue repair and regeneration therapies. |
Hepatocyte ß-Catenin Loss is Compensated by Insulin-mTORC1 Activation to Promote Liver Regeneration. Insulin-mTORC1 activation compensates for ß-catenin loss to enable LR after PH. mTORC1 signaling in hepatocytes itself is critical to both homeostasis and LR and is only partially compensated by ß-catenin activation. Dual inhibition of ß-catenin and mTOR may have notable untoward hepatotoxic side effects. |
Targeted decrease of portal hepatic pressure gradient improves ascites control after TIPS. Extend of PPG reduction and/or lowering of target PPG immediately after TIPS placement is associated with improved ascites control in the short term and with survival in the long term. A structured follow up visit for patients should assess persistence of ascites at 6 |
| Inflamm Bowel Dis |
Hospitalization Experiences and Post-traumatic Stress in Inflammatory Bowel Disease: Opportunities for Change. Patients with IBD consistently cite hospitalizations as potential sources of medical trauma. Poorly managed anxiety and pain demonstrate the greatest chance for IBD-PTS development. Gender and racial/ethnic differences emerged for these risks. Positive interactions with the medical team may help mitigate in-hospital IBD-PTS development. |
Increased Expression of Interleukin-13 Receptor in Ileum Associated With Nonresponse to Adalimumab in Ileal Crohn's Disease. Ileal histologic disease activity and IHC activation markers of chronic mucosal inflammation were not associated with 1-year ER. However, strong staining for IL-13 receptor in the ileum was associated with reduced odds of 1-year ER using adalimumab. Mucosal cellular disease profiles might pose an opportunity to guide treatment of CD. |
Patients With Stricturing or Penetrating Crohn's Disease Phenotypes Report High Disease Burden and Treatment Needs. Patients with complicated CD phenotypes reported higher rates of active CD-related luminal and extraintestinal manifestations, and underwent more surgeries, despite being more likely to have received biologics than those with CD-I. The potential for early recognition and management of CD-I to prevent progression to complicated phenotypes should be explored in longitudinal studies. |
| J Crohns Colitis |
Endoscopic Postoperative Recurrence In Crohn's Disease After Curative Ileocecal Resection With Early Prophylaxis By Anti-Tnf, Vedolizumab Or Ustekinumab: A Real-World Multicenter European Study. Prevention of ePOR within 1-year after surgery was successful in ~60% of patients. Patients treated with VDZ or UST consisted of a more refractory group. After controlling for confounders, no differences in ePOR risk were seen between anti-TNF prophylaxis and other groups. |
Patient Reported Outcomes: the ICHOM Standard Set for inflammatory bowel disease in real life practice helps quantify deficits in current care. Outcomes reported by patients illustrate the scale of the therapeutic deficit in current care. Proof of principle is demonstrated that PROM data can be collected continuously with little burden on healthcare professionals. This may become a metric for quality improvement programmes, or to compare outcomes. |
| J Hepatol |
Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB. JNJ-3989 plus an NA, with/without JNJ-6379 was well-tolerated and resulted in HBsAg reduction up to 336 days after the last JNJ-3989 Q4W dose. |
Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells. In contrast to physiological hepatocyte precursor cells and mature hepatocytes, HLC co-express liver and hybrid genes in the same cell. Targeted modification of the FXR gene regulatory network improves their differentiation by suppressing intestinal traits whilst inducing hepatocyte features. |
Plasma ammonia levels predict hospitalisation with liver-related complications and mortality in clinically stable outpatients with cirrhosis. Ammonia is an independent predictor of hospitalisation with liver-related complications and mortality in clinically stable outpatients with cirrhosis and performs better than traditional prognostic scores in predicting complications. |
| Neurogastroenterol Motil |
Effect of intracolonic volume on gastric sensory-motor responses in constipation-predominant irritable bowel syndrome. The volume of the colonic contents modulates satiety in patients with IBS-C, due to a general visceral pan-hypersensitivity. These effects should be considered in the choice of treatment for constipation in these patients. |
Exploring the pathophysiology of LARS after low anterior resection for rectal cancer with high-resolution colon manometry. The occurrence of more cyclic short antegrade motor patterns and less HAPC's (from the proximal to the mid-colon) is more prevalent in patients with major LARS. These findings help to understand the differences in pathophysiology in patients developing major versus no/minor bowel complaints after TME for rectal cancer. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
Review article: the epidemiologic burden of non-alcoholic fatty liver disease across the world. NAFLD poses a global public health problem with a very high disease burden in Asia, MENA and Latin America. Research is needed to better quantify the full impact of NAFLD and to develop strategies to improve awareness and risk stratification for this important liver disease. |
| Clin Gastroenterol Hepatol |
| Gastrointest Endosc |
| Gut |
Immunopathogenesis and environmental triggers in coeliac disease. One unsolved question concerns the considerable variability in disease penetrance, severity and presentation, pointing to the role of additional genetic and environmental factors that remain however uneasy to untangle and hierarchize. A current challenge is to transfer the considerable mechanistic insight gained into CD pathogenesis into benefits for the patients, notably to alleviate the gluten-free diet, a burden for many patients. |
| Hepatology |
Acute Hepatitis of Unknown Origin in Children: Behind the Statistics. Nevertheless, other hypotheses are being investigated to justify the severity of the clinical picture which is not typical of this type of virus. This review aims to summarize the current knowledge about the outbreak, highlight the suggested working hypotheses, and report the public health measures undertaken to tackle the outbreak. |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
| Clin Gastroenterol Hepatol |
| Gastroenterology |
| Gut |
Response to: Correspondence on "PICaSSO Histologic Remission Index (PHRI) in ulcerative colitis: development of a novel simplified histological score for monitoring mucosal healing and predicting clinical outcomes and its applicability in an artificial intelligence system" by Wong et al. |
| Hepatology |
| J Hepatol |
all remaining publications eg case reports, images of the month, etc…
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Inflamm Bowel Dis |
| J Hepatol |